Abstract
Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
MeSH terms
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Adenine / analogs & derivatives
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Adenine / pharmacology
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Administration, Oral
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Animals
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Cyclic Nucleotide Phosphodiesterases, Type 2
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Drug Evaluation, Preclinical
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Indoles / chemical synthesis
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Indoles / chemistry*
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Indoles / pharmacokinetics*
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Isoenzymes / drug effects
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Isoenzymes / physiology
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Molecular Structure
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Oxindoles
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Phosphodiesterase Inhibitors / chemical synthesis
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Phosphodiesterase Inhibitors / chemistry*
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Phosphodiesterase Inhibitors / pharmacokinetics*
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Phosphoric Diester Hydrolases* / drug effects
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Phosphoric Diester Hydrolases* / physiology
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Rats
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Solubility
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Structure-Activity Relationship
Substances
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Indoles
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Isoenzymes
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Oxindoles
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Phosphodiesterase Inhibitors
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2-oxindole
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9-(2-hydroxy-3-nonyl)adenine
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Phosphoric Diester Hydrolases
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Cyclic Nucleotide Phosphodiesterases, Type 2
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Pde2a protein, rat
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Adenine